Hemostasis: TISSEEL is a fibrin sealant indicated for use as an adjunct to hemostasis in adult and pediatric patients (>1 month of age) undergoing surgery when control of bleeding by conventional surgical techniques (such as suture, ligature, and cautery) is ineffective or impractical. TISSEEL is effective in heparinized patients.

Sealing: TISSEEL is a fibrin sealant indicated as an adjunct to standard surgical techniques (such as suture and ligature) to prevent leakage from colonic anastomoses following the reversal of temporary colostomies. 

For Topical Use Only. Do not inject TISSEEL directly into the circulatory system or into highly vascularized tissue. Intravascular application of TISSEEL can lead to intravascular coagulation, can result in life-threatening thromboembolic events, and can increase the likelihood and severity of acute hypersensitivity reactions in susceptible patients.

• Do not use TISSEEL in individuals with a known hypersensitivity to aprotinin.
• Apply TISSEEL as a thin layer by dripping or spraying using cannula or spray set.
• Do not use TISSEEL for the treatment of severe or brisk arterial or venous bleeding.
• Hypersensitivity or allergic/anaphylactoid reactions can occur with the use of TISSEEL.