#1 Veterinary Dentist recommended Petsmile is the only plaque and tartar control toothpaste accepted by the VOHC (Veterinary Oral Health Council). Petsmile’s proprietary formula Calprox is clinically proven to inhibit plaque and tartar buildup by gently dissolving the protein pellicle. Removing the pellicle leaves your pet’s teeth whiter and cleaner while improving gum health and providing kissable fresh breath. The protein pellicle is the thin bio-film that forms on the surface of the teeth, to which plaque, bacteria, and stains adhere. Petsmile is made in the USA with human-grade ingredients. It contains calcium, magnesium, phosphates, to re-mineralize enamel. Petsmile is BPA-free, silica-free, sulfate-free, paraben-free, gluten-free, allergy-free, and vegan.