BID (phospho Ser78) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7131-50, ES7131-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008],

Alternate Name: BID; BH3-interacting domain death agonist; p22 BID; BID

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: WB 1:500-2000, Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human BID around the phosphorylation site of Ser78. AA range:44-93

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 637

Human SWISS Prot NO: P55957

Subcellular Location: Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. When uncleaved, it is predominantly cytoplasmic.; [BH3-interacting domain death agonist p15]: Mitochondrion membrane. Translocates to mitochondria as an integral membrane protein.; [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Associated with the mitochondrial membrane.; [Isoform 1]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 2]: Mitochondrion membrane. A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.

Research Use Only