MRE11 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA27367-50, RA27367-100 Citations, Manuals and MSDS Available upon request. Background: MRE11 homolog, double strand break repair nuclease (MRE11) Homo sapiens This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. Alternative Names: MRE11A; HNGS1; MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A Applications: WB; IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Mouse; Rat; Monkey GeneID (Human): 4361 Protein MW (KDa): 80 SWISS: P49959 Source: Rabbit Research Use Only